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KMID : 0383820070620010067
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Tuberculosis and Respiratory Diseases
2007 Volume.62 No. 1 p.67 ~ p.70
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A Case of Concurrent Thymic Carcinoma with Systemic Lupus Erythematosus
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Lee Young-Joo
Lee Seung-Woo
Jung Soo-Jin
Choi Sang-Tae
Kim Se-Hyun
Jung Kyung-Soo
Yoon Sul-Hee
Kim Joo-Hang
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Abstract
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A thymic carcinoma is a rare malignant neoplasm of the thymus epithelium, which can be distinguished from a benign or invasive thymoma. Contrary to a thymoma, the association of a thymic carcinoma and autoimmune disease is rare, with only a few cases having been reported.Herein, a case of thymic carcinoma diagnosed concurrently with systemic lupus erythematosus (SLE) is reported. A 49 year-old man presented at our clinic with myalgia. He was diagnosed with SLE, based on an oral ulcer, lymphopenia, and positive ANA and anti-Sm antibodies. Incidentally, a routine chest X-ray showed a large mediastinal mass. Pathological examination of the mediastinal mass revealed an undifferentiated thymic carcinoma, of WHO classification type C. Further work-up for staging showed multiple bone and lung metastases. With a palliative aim, he received systemic chemotherapy, but refused further chemotherapy after the 2nd course. Currently, the patient has not been followed up since the chemotherapy.
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KEYWORD
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Thymic carcinoma, Systemic Lupus erythematosus, Autoimmune disease
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